Sofosvel, the global first generic oral tablet for pan-genotypic Chronic Hepatitis C treatment.

COMPOSITION Sofosvel Tablet: Each film coated tablet contains Sofosbuvir INN 400 mg and Velpatasvir INN 100 mg. Sofosvel is available at a price of USD 10 per tablet, so for 12 week treatment total cost will be USD 840 + Courier charge. PHARMACOLOGICAL INFORMATION Therapeutic class: Antiviral agent. PHARMACOLOGICAL ACTION Mechanism of Action Sofosbuvir is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is required for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. In a biochemical assay, GS-461203 inhibited the polymerase activity of the recombinant NS5B from HCV genotype 1b, 2a, 3a and 4a with an IC50 value ranging from 0.36 to 3.3 micromolar. GS-461203 is neither an inhibitor of human DNA and RNA polymerases nor an inhibitor of mitochondrial RNA polymerase. Velpatasvir is an inhibitor of the HCV NS5A protein, which is required for viral replication. Resistance selection in cell culture and cross-resistance studies indicate Velpatasvir targets NS5A as its mode of action. Pharmacodynamics Cardiac Electrophysiology The effect of Sofosbuvir 400 mg (recommended dosage) and 1200 mg (three times the recommended dosage) on QTc interval was evaluated in an active-controlled (Moxifloxacin 400 mg) thorough QT trial. At a dose three times the recommended dose, Sofosbuvir does not prolong QTc to any clinically relevant extent. The effect of Velpatasvir 500 mg (five times the recommended dosage) was evaluated in an active-controlled (Moxifloxacin 400 mg) thorough QT trial. At a dose five times the recommended dose, Velpatasvir does not prolong QTc interval to any clinically relevant extent. Pharmacokinetics The pharmacokinetic properties of the components of Sofosbuvir/Velpatasvir are provided in Table 1. Table 1: Pharmacokinetic properties of the Components of Sofosbuvir/Velpatasvir Specific Populations Pediatric Patients The pharmacokinetics of Sofosbuvir or Velpatasvir in pediatric patients has not been established. Geriatric Patients Population pharmacokinetic analysis in HCV-infected subjects showed that within the age range (18 to 82 years) analyzed, age did not have a clinically relevant effect on the exposure to Sofosbuvir, GS-331007 or Velpatasvir. Patients with Renal Impairment The pharmacokinetics of Sofosbuvir were studied in HCV negative subjects with mild (eGFR between 50 to less than 80 mL/min/1.73 m), moderate (eGFR between 30 to less than 50 mL/min/1.73 m2), severe renal impairment (eGFR less than 30 mL/min/1.73 m), and subjects with ESRD requiring hemodialysis following a single 400 mg dose of Sofosbuvir. Relative to subjects with normal renal function (eGFR greater than 80 mL/min/1.73 m2), the Sofosbuvir AUC was 61%, 107%, and 171% higher in subjects with mild, moderate, and severe renal impairment, while the GS-331007 AUC0-inf0-inf was 55%, 88%, and 451% higher, respectively. In subjects with ESRD, relative to subjects with normal renal function, Sofosbuvir and GS-331007 AUC was 28% and 1280% higher when Sofosbuvir was dosed 1 hour before hemodialysis compared with 60% and 2070% higher when Sofosbuvir was dosed 1 hour after hemodialysis, respectively. A 4 hour hemodialysis session removed approximately 18% of 0-inf administered dose. The pharmacokinetics of Velpatasvir were studied with a single dose of 100 mg Velpatasvir in HCV negative subjects with severe renal impairment (eGFR less than 30 mL/min by Cockcroft-Gault). No clinically relevant differences in Velpatasvir pharmacokinetics were observed between healthy subjects and subjects with severe renal impairment. Patients with Hepatic Impairment The pharmacokinetics of Sofosbuvir were studied following 7-day dosing of 400 mg Sofosbuvir in HCV-infected subjects with moderate and severe were 126% and 143% higher in moderate and severe hepatic impairment, while the GS-331007 AUC hepatic impairment (Child-Pugh Class B and C, respectively). Relative to subjects with normal hepatic function, the Sofosbuvir AUC were 18% and 9% higher, respectively. Population pharmacokinetics analysis in HCV-infected subjects indicated that cirrhosis (including decompensated cirrhosis) had no clinically relevant effect on the 0-24 exposure of Sofosbuvir and GS-331007. The pharmacokinetics of Velpatasvir were studied with a single dose of 100 mg Velpatasvir in HCV negative subjects with moderate and severe) was similar in subjects with moderate hepatic impairment, severe hepatic impairment, and control subjects with normal hepatic function. Population pharmacokinetics analysis in HCV- infected subjects hepatic impairment (Child-Pugh Class B and C). Velpatasvir plasma exposure (AUC inf indicated that cirrhosis (including decompensated cirrhosis) had no clinically relevant effect on the exposure of Velpatasvir. Race Population pharmacokinetics analysis in HCV-infected subjects indicated that race had no clinically relevant effect on the exposure of Sofosbuvir, GS-331007 or Velpatasvir. Gender Population pharmacokinetics analysis in HCV-infected subjects indicated that gender had no clinically relevant effect on the exposure of Sofosbuvir, GS-331007 or Velpatasvir. Drug Interaction Studies After oral administration of Sofosbuvir/Velpatasvir, Sofosbuvir is rapidly absorbed and subject to extensive first-pass hepatic extraction (hydrolysis followed by sequential phosphorylation) to form the pharmacologically active triphosphate. In clinical pharmacology studies, both Sofosbuvir and the primary circulating metabolite GS-331007 (dephosphorylated nucleotide metabolite) were monitored for purposes of pharmacokinetic analyses. Sofosbuvir and Velpatasvir are substrates of drug transporters P-gp and BCRP while GS-331007 is not. Velpatasvir is also transported by OATP1B1 and OATP1B3. In vitro, slow metabolic turnover of Velpatasvir by CYP2B6, CYP2C8, and CYP3A4 was observed. Inducers of P-gp and/or moderate to potent inducers of CYP2B6, CYP2C8, or CYP3A4 (e.g., Rifampin, St. John’s wort, Carbamazepine) may decrease plasma concentrations of Sofosbuvir and/or Velpatasvir, leading to reduced therapeutic effect of Sofosbuvir/ Velpatasvir. Coadministration with drugs that inhibit P-gp and/or BCRP may increase Sofosbuvir and/or Velpatasvir plasma concentrations without increasing GS-331007 plasma concentration. Drugs that inhibit CYP2B6, CYP2C8, or CYP3A4 may increase plasma concentration of Velpatasvir. Velpatasvir is an inhibitor of drug transporter P-gp, BCRP, OATP1B1, OATP1B3, and OATP2B1, and its involvement in drug interactions with these transporters is primarily limited to the process of absorption. At clinically relevant concentration, Velpatasvir is not an inhibitor of hepatic transporters OATP1A2 or OCT1, renal transporters OCT2, OAT1, OAT3 or MATE1, or CYP or UGT1A1 enzymes. THERAPEUTIC INDICATIONS Sofosvel is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infections: without cirrhosis or with compensated cirrhosis. with decompensated cirrhosis for use in combination with Ribavirin. DOSAGE AND ADMINISTRATION The recommended dosage of Sofosvel is one tablet taken orally once daily with or without food. Table 2 shows the recommended treatment regimen and duration based on patient population. Table 2: Recommended treatment regimen in patients with genotype 1, 2, 3, 4, 5 or 6 HCV ADVERSE REACTIONS The most common side effects observed with Sofosbuvir and Velpatasvir combination were Fatigue, Nausea, Headache, Anemia, Diarrhea, Insomnia, Pruritus, Muscle spasm, Dyspnea and Cough. There are some rare adverse events including reduced hemoglobin level, reduced lymphocyte count, reduced neutrophil count and reduced platelet count. Serious Symptomatic Bradycardia developed when Sofosbuvir is coadministered with Amiodarone and another HCV Direct Acting Antiviral. CONTRAINDICATIONS Sofosvel and Ribavirin combination regimen is contraindicated in patients for whom Ribavirin is contraindicated. Refer to the Ribavirin prescribing information for a list of contraindications for Ribavirin. DRUG INTERACTIONS Potential for Other Drugs to Affect Sofosbuvir/Velpatasvir Sofosbuvir and Velpatasvir are substrates of drug transporters P-gp and BCRP while GS-331007 (the predominant circulating metabolite of Sofosbuvir) is not. In vitro, slow metabolic turnover of Velpatasvir by CYP2B6, CYP2C8, and CYP3A4 was observed. Drugs that are inducers of P-gp and/or moderate to potent inducers of CYP2B6, CYP2C8, or CYP3A4 (e.g., Rifampin, St. John’s wort, Carbamazepine) may decrease plasma concentrations of Sofosbuvir and/or Velpatasvir, leading to reduced therapeutic effect of Sofosbuvir/Velpatasvir. The use of these agents with Sofosbuvir/Velpatasvir is not recommended. Sofosbuvir/Velpatasvir may be coadministered with P-gp, BCRP, and CYP inhibitors. Potential for Sofosbuvir/Velpatasvir to Affect Other Drugs Velpatasvir is an inhibitor of drug transporters P-gp, breast cancer resistance protein (BCRP), OATP1B1, OATP1B3, and OATP2B1. Coadministration of Sofosbuvir/Velpatasvir with drugs that are substrates of these transporters may increase the exposure of such drugs. Established and Potentially Significant Drug Interactions Table 3 provides a listing of established or potentially clinically significant drug interactions. The drug interactions described are based on studies conducted with either Sofosbuvir/Velpatasvir, the components of Sofosbuvir/Velpatasvir as individual agents, or are predicted drug interactions that may occur with Sofosbuvir/Velpatasvir. Table 3: Potentially Significant Drug Interactions: Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interaction. Drugs without Clinically Significant Interactions with Sofosbuvir/Velpatasvir Based on drug interaction studies conducted with the components of Sofosbuvir or Velpatasvir, no clinically significant drug interactions have been observed with the following drugs: Sofosbuvir/Velpatasvir: Atazanavir/Ritonavir, Cyclosporine, Darunavir/Ritonavir, Dolutegravir, elvitegravir/Cobicistat/Emtricitabine/Tenofovir/ Alafenamide, Emtricitabine, Raltegravir or Rilpivirine Sofosbuvir: Ethinyl Estradiol/Norgestimate, Methadone, or Tacrolimus Velpatasvir: Ethinyl Estradiol/Norgestimate, Ketoconazole, or Pravastatin. See Table 3 for use of Sofosbuvir/Velpatasvir with certain HIV antiretroviral regimens WARNINGS AND PRECAUTIONS Serious Symptomatic Bradycardia When Sofosbuvir Is Coadministered with Amiodarone and another HCV Direct Acting AntiviralCoadministration of Amiodarone with Sofosbuvir/Velpatasvir is not recommended. For patients taking Amiodarone who have no other alternative viable treatment options and who will be coadministered Sofosbuvir/Velpatasvir: Counsel patients about the risk of symptomatic bradycardia. Cardiac monitoring in an in-patient setting for the first 48 hours of coadministration is recommended, after which outpatient or self-monitoring of the heart rate should occur on a daily basis through at least the first 2 weeks of treatment. Patients who are taking Sofosbuvir/Velpatasvir who need to start Amiodarone therapy due to no other alternative viable treatment options should undergo similar cardiac monitoring as outlined above. Due to Amiodarone’s long half-life, patients discontinuing Amiodarone just prior to starting Sofosbuvir/Velpatasvir should also undergo similar cardiac monitoring as outlined above. Patients who develop signs or symptoms of bradycardia should seek medical evaluation immediately. Symptoms may include near-fainting or fainting, dizziness or lightheadedness, malaise, weakness, excessive tiredness, shortness of breath, chest pains, confusion, or memory problems. Risk of Reduced Therapeutic Effect Due to Concomitant Use of Sofosbuvir/Velpatasvir with Inducers of P-gp and/or Moderate to Potent Inducers of CYP Drugs that are inducers of P-gp and/or moderate to potent inducers of CYP2B6, CYP2C8, or CYP3A4 (e.g., Rifampin, St. John’s wort, Carbamazepine) may significantly decrease plasma concentrations of Sofosbuvir and/or Velpatasvir, leading to potentially reduced therapeutic effect of Sofosbuvir/Velpatasvir. The use of these agents with Sofosbuvir/Velpatasvir is not recommended. Risks Associated with Ribavirin and Sofosbuvir/Velpatasvir Combination Treatment If Sofosbuvir/Velpatasvir is administered with Ribavirin, the warnings and precautions for Ribavirin apply to this combination regimen. Refer to the Ribavirin prescribing information for a full list of the warnings and precautions for Ribavirin OVERDOSAGE No specific antidote is available for overdose with Sofosbuvir/Velpatasvir. If overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose with Sofosbuvir/Velpatasvir consists of general supportive measures including monitoring of vital signs as well as observation of the clinical status of the patient. Hemodialysis can efficiently remove the predominant circulating metabolite of Sofosbuvir, GS-331007, with an extraction ratio of 53%. Hemodialysis is unlikely to result in significant removal of Velpatasvir since Velpatasvir is highly bound to plasma protein. PHARMACEUTICAL INFORMATION Storage Conditions: Store in cool and dry place, away from light. Keep out of the reach of children. Presentation & Packaging Sofosvel Tablet: Each commercial box contains 6’s tablets in Alu-Alu blister pack. Manufactured By Beacon Pharmaceuticals Limited Mymensingh, Bangladesh With Regards, Faruk Hossain Executive. Business Development Department. WhatsApp, Viber, IMO, WeChat: + 88 01717 67 88 94 Mobile no.: + 88 01708 49 23 84 Email: faruk@beaconpharma.com.bd Skype: faruk.hossain.shadhin www.beaconpharma.com.bd Product Websites: www.darvoni.com & FB page: www.facebook.com/SofosbuivrDaclatasvir-326395681083254 www.tagrix.net & FB page: www.facebook.com/Tagrix.beacon www.sofosvel.com & FB page: www.facebook.com/Sofosvel-1559359161037823 www.crizonix.com & FB page: www.facebook.com/Crizonix-144178836001984

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সুমনের গান (যদি ভাবো কিনছ আমায় ভুল ভেবেছ)

যদি ভাবো কিনছো আমায় ভুল ভেবেছ,
কেনা যায় কণ্ঠ আমার দফা দফা
রুজি রোজগারের জন্য করছি রফা।
দু’হাতের আঙুলগুলো কিনতে পারো,
আপসেও নেই আপত্তি নেই আমারও।
আমাকে না আমার আপস কিনছো তুমি,
বলো কে জিতল তবে জন্মভুমি জন্মভুমি।
যদি ভাবো কিনছ আমায় ভুল ভেবেছ…

টাকাতেই চলছে সবার পাকস্থলী,
কেনা আর বেচা নিয়ে গেরস্থালি,
নীপাগারে রবীন্দ্রনাথ তেরেকেটে
বাজারের খাবার ঐ ঢুকছে পেটে
প্রতিবাদী কণ্ঠগুলো টাকার ব্যাপার,
প্রতিবাদ করতে গেলেও খাবার দাবার
সে তুমি শ্রমিক কিংবা তা ধিন ধা না
পেটে চাই খাবার নয়তো দিন চলে না দিন চলে না…

যদি ভাবো খাচ্ছো আমায় ভুল ভেবেছো,
খাওয়া যায় কণ্ঠ আমার দফা দফা
বদহজম হলেই কিন্তু দফা রফা
দুহাতের আঙুলগুলো খেতেও পারো,
আপসেও নেই আপত্তি নেই আমারও।
আমাকে না আমার আপস খাচ্ছো তুমি,
বলো কে জিতল তবে জন্মভুমি জন্মভুমি।
যদি ভাবো কিনছ আমায় ভুল ভেবেছ,

কেউ বেচে তার মেহনত হাতের পেশী
কেউ বেচে চুলের বাহার এলোকেশী,
কেউ বেচে প্রবন্ধ কোন পত্রিকাতে
আমি বেচি আমার কণ্ঠ তোমার হাতে
বেচি আমি আমার পদ্য সুরের ভাষা
বিরক্তি ঘেন্না এবং ভালোবাসা
আশাটাও পণ্য এখন বাজারদরে
বিকোতে পারলে টাকা আসবে ঘরে আসবে ঘরে…

বেচি দিন পাল্টে দেবার গানের জবান
কোনদিন হয়তো অন্য আর কোনো গান।
টাকাডুম টাকডুমাডুম নিয়ম ছেড়ে
মানুষের জন্যে সুদিন আনবে কেড়ে

যদি ভাবো কিনছ আমায় ভুল ভেবেছ……

সুমনের গান (তোমায় ছাড়াই বাঁচবো আমি)

তোমায় ছাড়াই বাঁচবো আমি,যেমন বাঁচে মাতৃহারা
গিরগিটিটা কিলবিলিয়ে,
যেমন বাঁচে গাছের চারা।

তোমায় ছাড়াই বাঁচবো আমি, যেমন বাঁচে পাখির ছানা,
ক্ষিদে পাওয়ার কান্না কেঁদেও হয় সে দারুণ পোষ না মানা।

তোমায় ছাড়াই গান বাঁধা যায়
উচ্চারণে আমি একা,
এই তো আমার হাতের রেখায় আমি আমার ভাগ্য রেখা।

তোমায় ছাড়াই বাঁচবো আমি, যেমন বাঁচে ফেরার খুনে,
গুহার ভেতর নেকড়ে হয়ে সময় কাটায় প্রহর গুণে।

তোমায় ছাড়াই বাঁচবো আমি, যেমন বাঁচে মান অভিমান,
ভাঙ্গে তবু মচকায় না, ছোট্ট-খাট্টো একখানি গান।

তোমায় ছাড়াই বাঁচবো আমি, যেমন বাঁচে বাল্য স্মৃতি,
চৌরঙ্গীর আলোর ভিড়ে ছেলেবেলার পল্লীগীতি।

তোমায় ছাড়াই বাঁচবো আমি, যেমন বাঁচে তোমায় চাওয়া,
দূর আকাশের তারার চোখে আমার চোখের কান্না পাওয়া !

সুমনের গান (নষ্ট সময়)

নষ্ট সময় একা একা লেখা কবিতা।
নষ্ট সময় একা একা নেওয়া নিশানা।
অক্ষর নিলে শব্দের বাঁক
ভাবিয়ে কবিতা তোমায় ভাবাক,
ভাবনায় খুঁজি অন্য যুগের ঠিকানা।

তোমারও ভাবনা দিগন্ত খুঁজে দূরে,
তোমারও ভাবনা সময়ের সীমানায়।
ঠিকানা হারিয়ে এই সমকাল
ছুঁয়েছে তোমার আমার সকাল,
যেমন হলুদ রোদ্দুর ছুঁয়ে যায়।

নষ্ট সময়ে আমিও নষ্ট হই।
দিনে দিনে শুধু অপচয় হয় সুর
অচেনা দিনের বিফল কথায়
প্রতি মুহূর্ত চলে যায়
তবুও ভাবনা কবিতায় ভরপুর।

তোমারও ভাবনা ডুবুরির মতো খুঁজে
অতল সাগরে গভীর নিরুদ্দেশ।
হয়তো কখনও আমরা দু’জন
খুঁজে পাবো সেই নীল নির্জন
দেখবো এই সময়ের শেষ।

অ্যালবাম : পাগলা সানাই

সুমনের গান (ক্যাকটাস তুমি কেঁদো না)

ক্যাকটাস তুমি কেঁদো না,
যীশুর মুকুটে কাঁটা
ছিল! তবুও তাঁর রক্তে
ভেসেছে জোয়ার-ভাটা।

পাথর তুমি কেঁদো না
তথাগত তিনি স্থাণু
তার ধ্যানস্থ রক্তে
চরাচর নতজানু।

আকাশ তুমি কেঁদো না
তোমারি মতো ফাঁকা
অনেকের বুকে কাঁদছে
বিবর্ণ বেঁচে থাকা।

ইতিহাস তুমি কেঁদো না
পরিবর্তন আসে
চিরক্লান্তির ভাবনা
তোমাকেই ভালোবেসে।

বন্ধু তুমি কেঁদো না
আমারও কান্না আছে
কাঁদি না তোমারই জন্য
তুমি ভেসে যাও পাছে।

অ্যালবাম : গানওয়ালা

Mr. Showbiz's CRITICS' Picks: The 100 Best Movies of All Time

The films chosen for this list were limited to English language films made since the birth of the talkies.

1.  Casablanca (1942), dir. Michael Curtiz 
2.  The Godfather Part II (1974), dir. Francis Ford Coppola
3.  North By Northwest (1959), dir. Alfred Hitchcock 
4.  Citizen Kane (1941), dir. Orson Welles 
5.  Lawrence of Arabia (1962), dir. David Lean
6. Manhattan (1979), dir. Woody Allen
7.  Gone With The Wind (1939), dir. Victor Fleming
8.  Chinatown (1974), dir. Roman Polanski
9. The Man Who Shot Liberty Valance (1962), dir. John Ford
10.  City Lights (1931), dir. Charles Chaplin 
11.  Raging Bull (1980), dir. Martin Scorsese 
12.  Sunset Boulevard (1950), dir. Billy Wilder 
13.  2001: A Space Odyssey (1968), dir. Stanley Kubrick 
14.  The Philadelphia Story (1940), dir. George Cukor 
15. To Have and Have Not (1944), dir. Howard Hawks
16.  The Graduate (1967), dir. Mike Nichols 
17.  The Maltese Falcon (1941), dir. John Huston 
18.  Star Wars (1977), dir. George Lucas
19.  It's A Wonderful Life (1946), dir. Frank Capra 
20.  The Wild Bunch (1969), dir. Sam Peckinpah
21.  Vertigo (1958), dir. Alfred Hitchcock 
22.  Singin' In The Rain (1952), dir. Stanley Donen and Gene Kelly 
23.  The Godfather (1972), dir. Francis Ford Coppola
24.  E.T. - The Extra-Terrestrial (1982), dir. Steven Spielberg 
25. The Palm Beach Story (1942), dir. Preston Sturges
26.  Blade Runner (1982), dir. Ridley Scott
27.  Double Indemnity (1944), dir. Billy Wilder 
28. The Manchurian Candidate (1962), dir. John Frankenheimer
29.  All About Eve (1950), dir. Joseph Mankiewicz
30.  The Searchers (1956), dir. John Ford 
31.  Rear Window (1954), dir. Alfred Hitchcock 
32.  Annie Hall (1977), dir. Woody Allen 
33.  Ninotchka (1939), dir. Ernst Lubitsch 
34. Blue Velvet (1986), dir. David Lynch
35.  The Wizard of Oz (1939), dir. Victor Fleming 
36.  Bringing Up Baby (1938), dir. Howard Hawks 
37.  The Bridge On The River Kwai (1957), dir. David Lean 
38.  Dr. Strangelove or: How I Learned To Stop Worrying And Love The Bomb (1964), dir. Stanley Kubrick 
39.  Pulp Fiction (1994), dir. Quentin Tarantino
40.  Some Like It Hot (1959), dir. Billy Wilder 
41.  On The Waterfront (1954), dir. Elia Kazan 
42.  One Flew Over The Cuckoo's Nest (1975), dir. Milos Forman 
43.  Taxi Driver (1976), dir. Martin Scorsese
44.  Touch Of Evil (1958), dir. Orson Welles 
45.  Nashville (1975), dir. Robert Altman 
46.  Apocalypse Now (1979), dir. Francis Ford Coppola 
47. The Hustler (1961), dir. Robert Rossen
48.  The Big Sleep (1946), dir. Howard Hawks 
49.  Bonnie And Clyde (1967), dir. Arthur Penn 
50. Unforgiven (1992), dir. Clint Eastwood
51. Network (1976), dir. Sidney Lumet
52. The Silence of the Lambs (1991), dir. Jonathan Demme
53.  Jaws (1975), dir. Steven Spielberg
54. The Deer Hunter (1978), dir. Michael Cimino
55. Hannah and Her Sisters (1986), dir. Woody Allen
56. Gunga Din (1939), dir. George Stevens
57.  Schindler's List (1993), dir. Steven Spielberg
58. Hud (1963), dir. Martin Ritt
59.  The Third Man (1949), dir. Carol Reed 
60.  Modern Times (1936), dir. Charles Chaplin 
61. Raiders of the Lost Ark (1981), dir. Steven Spielberg
62.  Red River (1948), dir. Howard Hawks 
63. The Empire Strikes Back (1980), dir. Irvin Kershner
64. Hamlet (1948), dir. Laurence Olivier
65.  Notorious (1946), dir. Alfred Hitchcock 
66.  A Streetcar Named Desire (1951), dir. Elia Kazan 
67. Last Tango in Paris (1972), dir. Bernardo Bertolucci
68. Sweet Smell of Success (1957), dir. Alexander Mackendrick
69.  Out Of The Past (1947), dir. Jacques Tournier 
70. All That Jazz (1979), dir. Bob Fosse
71.  Top Hat (1935), dir. Mark Sandrich 
72. The Misfits (1961), dir. John Huston
73. Tootsie (1982), dir. Sydney Pollack
74.  Mr. Smith Goes to Washington (1939), dir. Frank Capra
75. Short Cuts (1993), dir. Robert Altman
76.  The Grapes of Wrath (1940), dir. John Ford 
77. The Apartment (1960), dir. Billy Wilder
78. A Clockwork Orange (1971), dir. Stanley Kubrick
79.  Psycho (1960), dir. Alfred Hitchcock 
80. Moonstruck (1987), dir. Norman Jewison
81. GoodFellas (1990), dir. Martin Scorsese
82.  Stagecoach (1939), dir. John Ford 
83. The Last Picture Show (1971), dir. Peter Bogdanovich
84. Die Hard (1988), dir. John McTiernan
85.  Midnight Cowboy (1969), dir. John Schlesinger 
86.  West Side Story (1961), dir. Robert Wise, Jerome Robbins
87.  The Quiet Man (1952), dir. John Ford 
88. Reds (1981), dir. Warren Beatty
89.  Rebel Without a Cause (1955), dir. Nicholas Ray
90. A Hard Day's Night (1964), dir. Richard Lester
91. A Room With A View (1986), dir. James Ivory
92. From Here to Eternity (1953), dir. Fred Zinnemann
93. The Piano (1993), dir. Jane Campion
94. Adam's Rib (1949), dir. George Cukor
95. This Is Spinal Tap (1984), dir. Rob Reiner
96.  It Happened One Night (1934), dir. Frank Capra
97. Do the Right Thing (1989), dir. Spike Lee
98. The Thin Man (1934), dir. W.S. Van Dyke
99. Patton (1970), dir. Franklin Schaffner
100. The Terminator (1984), dir. James Cameron